Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans
| 论文编号: | |||||||||
| 作者: | Xu YK | ||||||||
| 刊物名称: | Journal of Natural Products | ||||||||
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| 论文题目英文: | Koumine, Humantenine, and Yohimbane Alkaloids from Gelsemium elegans | ||||||||
| 年: | Jun 2015 | ||||||||
| 卷: | online | ||||||||
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| 联系作者: | Xu YK | ||||||||
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| 影响因子: | 3.798 | ||||||||
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| 摘要: | Nine new alkaloids of the koumine (1−4), humantenine (5−7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first norhumantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6−9.3 μM. | ||||||||
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