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张玉梅

性别:

职称:研究员

邮箱:zymei@xtbg.ac.cn

研究方向:

抗糖尿病及抗肝纤维化天然产物化学、药理学研究及相关新药研发
学习经历
2015-04--2015-07   The University of North Carolina at Chapel Hill   高级访问学者
2002-03--2005-01   中国科学院昆明植物研究所   博士
1997-09--2000-06   云南农业大学   硕士
1993-09--1997-06   西南师范大学   学士
 
工作经历
2018-12~现在, 中国科学院西双版纳热带植物园, 研究员
2012-10~现在, 中国科学院西双版纳热带植物园, 副研究员
2008-01~2012-09,中国科学院昆明植物研究所, 副研究员
2005-03~2007-12,中国科学院昆明植物研究所, 助理研究员
2000-07~2002-02,云南省环境科学研究所, 助理工程师
 

代表论著

1. Han-Lei Wang?, Kun Zhang?, Xue-Lin Chen, Mei Han, Jing Lu, Yu-Mei Zhang*. In vitro and in vivo evaluation of antidiabetic properties and mechanisms of Ficus tikoua Bur. Nutrients. 2022, 14,4413

2. Xue-Lin Chen, Bing Li, Xia Zhao, Li-hong Li, Han-Lei Wang, Kun Zhang, Mei Han, Yumei Zhang*. Kochiae Fructus: Evaluation on the antioxidant properties and oral safety of its water decoction. Toxicon. 2022, 219, 16934

3. Xue-Lin Chen, Kun Zhang, Ji-Yan Ni, Xia Zhao, Yu-Mei Zhang*. α-GLUCOSIDASE INHIBITORY CONSTITUENTS FROM Trichosanthis Radix. Chemistry of Natural Compounds. 2022, 58 (5), 796-798

4. Kun Zhang , Mei Han, Xia Zhao, Xuelin Chen, Hanlei Wang, Jiyan Ni, Yumei Zhang *. Hypoglycemic and Antioxidant Properties of Extracts and Fractions from Polygoni Avicularis Herba. Molecules, 2022, 27(11), 3381.

5. Bin-Bin Fan, Jia-Xiang Liu, Hai-Jun Hu, Yu-Mei Zhang*. A new triterpene from Metadina trichotoma. Chemistry of Natural Compounds. 2022, 58 (2), 297-300

6. Han-Lei Wang, Ran Zhang, Kun Zhang, Yu-Mei Zhang*. Antioxidant, Hypoglycemic and Molecular Docking Studies of Methanolic Extract, Fractions and Isolated Compounds from Aerial Parts of Cymbopogon citratus (DC.) Stapf. Molecules. 2022, 27(9), 2858.

7. Kun Zhang, Xue-Lin Chen, Xia Zhao, Ji-Yan Ni, Han-Lei Wang, Mei Han, Yu-Mei Zhang*. Antidiabetic potential of Catechu via assays for α-glucosidase, α-amylase, and glucose uptake in adipocytes. Journal of Ethnopharmacology. 2022, 291115118

8. Xu Cai, Qi-Shi Song, Jian-Kun Yang, Zhi-Yuan Lu, Ke-Li Chen, Yu-Mei Zhang*. Chemical constituents from Afzelia xylocarpa (Kurz) Craib. Chemistry of Natural Compounds. 2018, 54 (4),764-765.

9. Zhang-Hua Sun, Ning-Hua Tan, Guang-Zhi Zeng, Yu-Mei Zhang*. Two New Cinnamyl Isovalerate Derivatives from Sabina gaussenii. Molecules. 2016, 21(5), 571.

10. Jian Xu, Guang-Zhi Zeng, Yi-Mei Liu, Ke-Li Chen, Zhang-Hua Sun, Yu-Mei Zhang*, Ning-Hua Tan*. Sesquiterpenoids and Diterpenes from Chamaecyparis obtusa var. breviramea f. crippsii. Z. Naturforsch. 2014, 69b, 362-368.

11. Jian Xu, Ning-Hua Tan*, Yu-Mei Zhang*, et al. A New Lignan Glycoside from Chamaecyparis obtusa var. breviramea f. crippsii. Natural Product communications. 2014, 9(2), 215-216 .

12. Yu-Mei Zhang*, Jian Xu, Lin Xiao, Ning-Hua Tan*, et al. A New Phenolic Glycoside from Chamaecyparis obtusa var. breviramea f. crippsii. Molecules. 2013, 18(1), 1255-1261.

13. Wen Jun He, Yu-Mei Zhang*, Ning-Hua Tan*, et al. Terpene and lignan glycosides from the twigs and leaves of an endangered conifer, Cathaya argyrophylla. Phytochemistry. 2012, 83: 63-69.

14. Wen-Jun He, Hong-Biao Chu, Yu-Mei Zhang*, Ning-Hua Tan*, et al. Antimicrobial, Cytotoxic Lignans and Terpenoids from the Twigs of Pseudolarix kaempferi. Planta medica. 2011, 77: 1924-1931.

15. Hong-Biao Chu, Ning-Hua Tan*, Yu-Mei Zhang*, et al. Chemical Constituents of Pedicularis densispica Franch. Z. Naturforsch. 2011, 66b, 641-646.

16. Yu-Mei Zhang, Ning-Hua Tan*, et al. A new abietane diterpene from Glyptostrobus pensilis. Fitoterapia, 2010, 81, 1202-1204.

17. Wen Bing Zhou, Yu Mei Zhang*, Ning Hua Tan*, et al. Three new antiviral triterpenes from Aster tataricus. Z. Naturforsch, 2010, 65b, 1393-139.

18. Yu Mei Zhang, Ning Hua Tan*, et al. A new norlignan fromTaxodium ascendens. Fitoterapia, 2009, 80(6), 361-363.

19. Yu-Mei Zhang, Ning-Hua Tan*, Yang Lu, Ying Chang, Rui-Rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9(22): 4579-4581.

20.Yu-Mei Zhang, Ning-Hua Tan*, Huo-Qiang Huang, Guang-Zhi Zeng. Triterpernoid saponins from Metadina trichotoma. Z. Naturforsch. 2007, 62b: 745-748.

21. Yu-Mei Zhang, Ning-Hua Tan*, Ya-Bing Yang, Yang Lu, Peng Cao, Yun-Shan Wu. Norlignans from Sequoia sempervirens. Chemistry & Biodiversity, 2005, 2: 497-505.

22. Yu-Mei Zhang, Ning-Hua Tan*, Min He, Yang Lu, Su-Qin Shang, Qi-Tai Zheng. Sequosempervirin A, a novel spirocyclic compound from Sequoia sempervirens. Tetrahedron Letters, 2004, 45: 4319-43.


承担科研项目情况

1 ) 三种裸子植物抗肿瘤活性成分及其细胞凋亡作用机制研究, 主持,国家级, 2010-01--2012-12

2 ) 叶子花属植物中三萜皂苷的胰岛素增敏活性及作用机制研究, 主持, 省级, 2014-10--2017-09

3 ) 光叶子花中两个三萜皂苷的抗二型糖尿病作用研究, 主持, 部委级, 2016-11--2018-06

4 ) 光叶子花中两个抗二型糖尿病三萜皂苷的成药性研究, 主持, 部委级, 2017-01--2018-12

5 ) 傣药龙血竭与光叶子花的抗糖尿病活性研究, 主持, 部委级, 2017-10--2020-12

6 ) 抗2型糖尿病药物zym01的临床前个性化特征研究, 主持, 部委级, 2019-01--2020-09

7 2种云南特色植物中抗糖尿病活性成分的研究,主持,省级,2021.6-2023.12

8 ) 抗器官组织纤维化的中药民族药单体成分的快速发现关键技术研究, (子任务)主持, 国家级, 2019-01--2020-12

9 ) 降糖候选新药GymP的技术成果转让与合作开发, 主持, 研究所(企业), 2020-09--2040-08